“No one organization or sector alone can bring a scientific discovery through product development. The process takes years and often requires participation from patient advocates, academia, industry, and government. … Stakeholders in R&D increasingly look to foundations to be the ‘honest brokers’ to lead these collaborations. Building and sustaining a collaborative venture with sometimes competing interests, however, is not for the faint of heart and is a far cry from the individual grant-making process that foundations have focused on in the past. In April 2017, FasterCures convened a select group of foundation leaders and other stakeholders to take the conversation about the partnerships that venture philanthropies are leading to a new level of specificity … We examined different types of relationships and agreement structures, how the agreements originate and what’s necessary to sustain them, and how partners are addressing legal and cultural challenges that can divide them.” This report captures key insights from that convening.