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“Climate change will exacerbate current and create new health risks. Because many upstream drivers of these risks arise from outside the sector, multi-sectoral approaches are required for effective adaptation. This paper focuses on showcasing successful stories of collaboration from four relevant arenas — One Health, Disaster Risk Management, the Commission on Social Determinants of Health, and Health in All Policies (HiAP). Common themes from these case studies include first, the importance of systems-based approaches incorporating partnership with all relevant sectors, and second structural supports, including leadership, sufficient resources and responsive governments, are necessary to provide the supporting conditions for collaboration and partnerships.”