The Elizabeth River, 23 miles of estuary on the southern end of Chesapeake Bay, has one of the busiest commercial ports in the world. A history of industrial pollution, however, contributed to sediment contamination and “toxic hotspots” along the river. In response, Marjorie Mayfield Jackson helped launch the Elizabeth River Project in 1993 to “restore the river to the highest practical level of environmental quality.” Its 2003 “State of the River” report highlighted a particular hotspot in the southern branch of the river at Money Point, where, for decades, wood treatment facilities allowed creosote to pool on the river floor; the study showed cancer rates of 38 percent and precancerous lesions of 83 percent among the small mummichog fish. As Executive Director, Marjorie spearheaded the cleanup of Money Point, collaborating with industries, citizens, and governments. Their joint efforts helped to lower cancer rates among the mummichog to less than seven percent in the initial cleanup area. Stakeholders have worked collaboratively on dozens of other projects, including reducing future pollution and restoring wetlands, setting a goal for the entire Elizabeth River to be both swimmable and fishable by 2020.